Cutting edge: Evidence for a dynamically driven T cell signaling mechanism.

Cutting edge: OX40 inhibits TGF-beta- and antigen-driven conversion of naive CD4 T cells into CD25+Foxp3+ T cells.

Naive CD4 T cells can develop into regulatory T cells by acquiring the transcription factor Foxp3. Combined signals from the TCR, CD28, IL-2R, and TGF-beta R promote Foxp3 expression in activated naive CD25(-) CD4 T cells. Here we show that OX40 (CD134) signaling inhibits TGF-beta-driven Foxp3 mRNA and suppresses the conversion of naive Ag-specific transgenic CD4 T cells into CD25(+)Foxp3(+) T ...

Antiviral Cd4 T Cell Response Il-2 Signaling Is Sustained during Early Cutting Edge: Paracrine, but Not Autocrine

Microclusters and Is Active in Signaling Activation of T Cells Is Recruited to Cutting Edge: Cell Surface Linker for

Recent Advances in T Cell Signaling in Aging

The immune system of mammalian organisms undergoes alterations that may account for an increased susceptibility to certain infections, autoimmune diseases, or malignancies. Well characterized are age related defect in T cell functions and cell mediated immunity. Although it is well established that the functional properties of T cells decrease with age, its biochemical and molecular nature is...

Experimental Study of the Effect of Laser-Cutting Process Parameters on Heat Distribution and Cutting Edge Quality of Steel Sheets

This study aimed to evaluate Laser-cutting process of Mild Steel St37 sheets with two different thicknesses. In order to evaluate the quality of cutting edge and the depth of the area affected by the heat, several tests were conducted to determine the effect of parameters such as Laser power, Laser beam movement speed and pressure of axillary gas on the quality of cutting edge and the depth of ...